In 1979, Professor Carpentier and Edwards Lifesciences began the development of a pericardial valve in an attempt to improve upon the earlier pericardial valve designs. The aortic Carpentier-Edwards PERIMOUNT Pericardial Bioprosthesis was introduced internationally in 1980, and in the United States in October of 1991. The pericardial valve is a biomechanically engineered valve that can be described as a mechanical valve with a biologic component. In this way, it differs from a porcine (pig) stented valve which incorporates a natural pig’s valve.
There are three aortic models available, two in the U.S. and one outside the U.S. The U.S. models are the Carpentier-Edwards PERIMOUNT Pericardial Bioprosthesis (Model 2700) and the Carpentier- Edwards PERIMOUNT RSR (reduced sewing ring) Pericardial Bioprosthesis (Model 2800). The international model is the Carpentier-Edwards PERIMOUNT Pericardial Bioprosthesis (Model 2900).
In addition, there are two mitral models of the PERIMOUNT valve. The Carpentier-Edwards PERIMOUNT Pericardial Bioprosthesis (Model 6900) and the Carpentier-Edwards PERIMOUNT Plus Pericardial Bioprosthesis (Model 6900P) (available outside the USA only).
The Carpentier-Edwards PERIMOUNT Bioprostheses are constructed from three pieces of bovine (cow) pericardial tissue. Tissue is cut out from a carefully selected region of cow tissue surrounding the heart. The tissue is mounted on a lightweight frame that is covered with a porous, knitted polytetrafluoroethylene (PTFE) cloth. A sewing ring made of molded silicone rubber covered by polytetrafluoroethylene cloth enables the surgeon to sew the valve into the patient.